Pigment Epithelium-Derived Factor, a Protective Factor for Photoreceptors in Vivo

Federica Polato; S Patricia Becerra

doi:10.1007/978-3-319-17121-0_93

Pigment Epithelium-Derived Factor, a Protective Factor for Photoreceptors in Vivo

Adv Exp Med Biol. 2016:854:699-706. doi: 10.1007/978-3-319-17121-0_93.

Authors

Federica Polato¹, S Patricia Becerra²

Affiliations

¹ Section of Protein Structure and Function, Laboratory of Retinal Cell and Molecular Biology, NEI, National Institutes of Health, NIH-NEI BG.6. Room 134. 6 Center Drive MSC 0608, 20892-0608, Bethesda, MD, USA. polatof@mail.nih.gov.
² Section of Protein Structure and Function, Laboratory of Retinal Cell and Molecular Biology, NEI, National Institutes of Health, NIH-NEI BG.6. Room 134. 6 Center Drive MSC 0608, 20892-0608, Bethesda, MD, USA. becerras@nei.nih.gov.

Abstract

Pigment epithelium-derived factor (PEDF) is a natural protein of the retina with demonstrable neurotrophic properties, found in the interphotoreceptor matrix in intimate contact with photoreceptors. This review summarizes the effects of PEDF on photoreceptors in several animal models of retinal degeneration.

Keywords: Animal models; Neuroprotection; PEDF; Photoreceptor; Retinal degeneration.

Publication types

Review

MeSH terms

Animals
Disease Models, Animal
Eye Proteins / genetics
Eye Proteins / metabolism*
Genetic Predisposition to Disease / genetics
Humans
Mutation
Nerve Growth Factors / genetics
Nerve Growth Factors / metabolism*
Photoreceptor Cells, Vertebrate / metabolism*
Protective Agents / metabolism*
Retinal Degeneration / genetics
Retinal Degeneration / metabolism*
Serpins / genetics
Serpins / metabolism*

Substances

Eye Proteins
Nerve Growth Factors
Protective Agents
Serpins
pigment epithelium-derived factor

Grants and funding

Z01 EY000438/ImNIH/Intramural NIH HHS/United States