A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects

Adv Exp Med Biol. 2016:854:177-83. doi: 10.1007/978-3-319-17121-0_24.

Abstract

Mouse models provide important resources for many areas of vision research, pertaining to retinal development, retinal function and retinal disease. The Translational Vision Research Models (TVRM) program uses chemical mutagenesis to generate new mouse models for vision research. In this chapter, we report the identification of mouse models for Grm1, Grk1 and Lrit3. Each of these is characterized by a primary defect in the electroretinogram. All are available without restriction to the research community.

Keywords: Electroretinogram; Mice; Mutagenesis; Photoreceptor; Retina.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alleles
  • Animals
  • Disease Models, Animal
  • Electroretinography
  • Eye Diseases / diagnosis
  • Eye Diseases / genetics
  • Eye Diseases / physiopathology
  • G-Protein-Coupled Receptor Kinase 1 / genetics
  • Genetic Predisposition to Disease / genetics*
  • Genetic Testing / methods
  • Humans
  • Male
  • Membrane Proteins / genetics
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Mutagenesis
  • Mutation*
  • Receptors, Metabotropic Glutamate / genetics
  • Retina / metabolism*
  • Retina / pathology
  • Retina / physiopathology
  • Retinal Diseases / diagnosis
  • Retinal Diseases / genetics*
  • Translational Research, Biomedical / methods
  • Vision, Ocular / genetics
  • Vision, Ocular / physiology

Substances

  • Lrit3 protein, mouse
  • Membrane Proteins
  • Receptors, Metabotropic Glutamate
  • metabotropic glutamate receptor type 1
  • G-Protein-Coupled Receptor Kinase 1
  • Grk1 protein, mouse