Abstract
Schizophrenia affects about 1% of the population. Its etiology is not fully understood. Environmental conditions certainly contribute to the development of schizophrenia, but the determining factor is genetic predisposition: the coefficient of heritability of schizophrenia is about 80%, which is typical for the most highly heritable multifactorial diseases. Polymorphic loci of genes of enzymes and receptors involved in the processes of neuroprotection and neurotrophia play significant role in the development of this disease. In this paper we investigated 48 polymorphic variants of genes of the neurotrophins and neurexins family (BDNF, NTRK2, NTRK3, NGF, NXPH1, and NRXN1) in Russian and Tatar cases and in a control group living in the Republic of Bashkortostan. The results of this study confirm the important role of neurotrophin and neurexin genes in paranoid schizophrenia development.
MeSH terms
-
Adult
-
Bashkiria / ethnology
-
Brain-Derived Neurotrophic Factor / genetics
-
Calcium-Binding Proteins
-
Case-Control Studies
-
Cell Adhesion Molecules, Neuronal / genetics
-
Ethnicity
-
Female
-
Genetic Predisposition to Disease
-
Glycoproteins / genetics
-
Humans
-
Male
-
Membrane Glycoproteins / genetics
-
Nerve Growth Factor / genetics
-
Nerve Growth Factors / genetics*
-
Nerve Tissue Proteins / genetics
-
Neural Cell Adhesion Molecules
-
Neuropeptides / genetics
-
Polymorphism, Single Nucleotide*
-
Protein-Tyrosine Kinases / genetics
-
Receptor, trkB
-
Receptor, trkC / genetics
-
Schizophrenia, Paranoid / ethnology
-
Schizophrenia, Paranoid / genetics*
Substances
-
Brain-Derived Neurotrophic Factor
-
Calcium-Binding Proteins
-
Cell Adhesion Molecules, Neuronal
-
Glycoproteins
-
Membrane Glycoproteins
-
NGF protein, human
-
NRXN1 protein, human
-
Nerve Growth Factors
-
Nerve Tissue Proteins
-
Neural Cell Adhesion Molecules
-
Neuropeptides
-
neurexophilin
-
BDNF protein, human
-
Nerve Growth Factor
-
Protein-Tyrosine Kinases
-
Receptor, trkB
-
Receptor, trkC
-
tropomyosin-related kinase-B, human