Abstract
A relationship between the presence of amyloidosis and SAA1 genotype has been shown in recent studies of (principally) familial Mediterranean fever patients. We found that the SAA1 rs12218 polymorphism was significantly more prevalent in ankylosing spondylitis patients with amyloidosis.
Keywords:
Amyloidosis; ankylosing spondylitis; type 1/type 2 serum amyloid A protein genes.
MeSH terms
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Adult
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Alleles
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Amyloidosis / complications
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Amyloidosis / genetics*
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Amyloidosis / pathology
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Creatinine / blood
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Cytoskeletal Proteins / genetics
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Familial Mediterranean Fever / complications
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Familial Mediterranean Fever / genetics*
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Familial Mediterranean Fever / pathology
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Female
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Gene Expression
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Gene Frequency
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Humans
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Male
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Middle Aged
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Mutation*
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Polymorphism, Single Nucleotide*
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Proteinuria / pathology
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Proteinuria / urine
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Pyrin
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Serum Amyloid A Protein / genetics*
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Spondylitis, Ankylosing / complications
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Spondylitis, Ankylosing / genetics*
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Spondylitis, Ankylosing / pathology
Substances
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Cytoskeletal Proteins
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MEFV protein, human
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Pyrin
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SAA1 protein, human
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SAA2 protein, human
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Serum Amyloid A Protein
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Creatinine