PACAP as a neuroprotective factor in ischemic neuronal injuries

Seiji Shioda; Tomoya Nakamachi

doi:10.1016/j.peptides.2015.08.006

PACAP as a neuroprotective factor in ischemic neuronal injuries

Peptides. 2015 Oct:72:202-7. doi: 10.1016/j.peptides.2015.08.006. Epub 2015 Aug 11.

Authors

Seiji Shioda¹, Tomoya Nakamachi²

Affiliations

¹ Global Research Center for Innovative Life Science, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. Electronic address: shioda@med.showa-u.ac.jp.
² Laboratory of Regulatory Biology, Graduate School of Science and Engineering, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan.

PMID: 26275482
DOI: 10.1016/j.peptides.2015.08.006

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family. PACAP and its three receptor subtypes are expressed in neural tissues, with PACAP known to exert pleiotropic effects on the nervous system. This review provides an overview of current knowledge regarding the neuroprotective effects, mechanisms of action, and therapeutic potential of PACAP in response to ischemic brain injuries.

Keywords: CRMP2; DNA microarray analysis; Ischemia; Neuronal death; PACAP; PACAP receptors.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Brain Ischemia* / drug therapy
Brain Ischemia* / metabolism
Brain Ischemia* / pathology
Humans
Neurons / metabolism*
Neurons / pathology
Neuroprotective Agents* / metabolism
Neuroprotective Agents* / therapeutic use
Pituitary Adenylate Cyclase-Activating Polypeptide* / metabolism
Pituitary Adenylate Cyclase-Activating Polypeptide* / therapeutic use
Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide / metabolism

Substances

ADCYAP1 protein, human
Neuroprotective Agents
Pituitary Adenylate Cyclase-Activating Polypeptide
Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide