Physiological role of NBCe2 in the regulation of electrolyte transport in the distal nephron

Am J Physiol Renal Physiol. 2015 Sep 15;309(6):F489-91. doi: 10.1152/ajprenal.00192.2015. Epub 2015 Jul 1.

Abstract

The electrogenic Na(+)-HCO3 (-) cotransporter 2 (NBCe2) is a newly discovered protein in the distal nephron. Our understanding is minimal regarding its physiological role in renal electrolyte transport. In this mini-review, we summarize the potential function of NBCe2 in the regulation of blood pressure, acid-base, and K(+) and Ca(2+) transport in the distal nephron.

Keywords: Ca2+; K+; NBCe2; acid-base; hypertension.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Electrolytes / metabolism*
  • Humans
  • Hypertension, Renal / metabolism
  • Kidney / metabolism
  • Nephrons / metabolism*
  • Sodium-Bicarbonate Symporters / metabolism*
  • Water-Electrolyte Balance / physiology

Substances

  • Electrolytes
  • Sodium-Bicarbonate Symporters