Associations of ABHD2 genetic variations with risks for chronic obstructive pulmonary disease in a Chinese Han population

PLoS One. 2015 Apr 16;10(4):e0123929. doi: 10.1371/journal.pone.0123929. eCollection 2015.

Abstract

The human α/β hydrolase domain-containing protein 2 gene (ABHD2) plays a critical role in pulmonary emphysema, a major subset of the clinical entity known as chronic obstructive pulmonary disease (COPD). Here, we evaluated genetic variation in the ABHD2 gene in a Chinese Han population of 286 COPD patients and 326 control subjects. The rs12442260 CT/CC genotype was associated with COPD (P < 0.001) under a dominant model. In the former-smoker group, the rs12442260 TT genotype was associated with a decreased risk of developing COPD after adjusting for age, gender and pack-years (P = 0.012). Rs12442260 was also associated with pre-FEV1 (the predicted bronchodilator forced expiratory volume in the first second) in controls (P = 0.027), but with FEV1/ forced vital capacity (FVC) ratios only in COPD patients (P = 0.012) under a dominant model. Results from the current study suggest that ABHD2 gene polymorphisms contribute to COPD susceptibility in the Chinese Han population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Asian People / genetics
  • Case-Control Studies
  • Female
  • Forced Expiratory Volume / genetics
  • Genetic Predisposition to Disease
  • Humans
  • Hydrolases / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Pulmonary Disease, Chronic Obstructive / genetics*

Substances

  • Hydrolases
  • ABHD2 protein, human

Grants and funding

This study was funded by the National Natural Science Foundation of China (30900413), Science Foundation of Heilongjiang Province of China (LC201024), the National Basic Science Research Program of China (973 Program) (grant no. 2012CBA01303).