Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis

Anticancer Res. 2015 Mar;35(3):1459-64.

Abstract

Background: The function of phosphatidylserine-specific phospholipase A1 (PS-PLA1), a phospholipase that acts specifically on phosphatidylserine and produces lysophosphatidylserine, a lysophospholipid mediator, has not been fully elucidated. We evaluated the role of PS-PLA1 in oncogenesis and metastasis of colorectal cancer (CRC).

Materials and methods: Specimens from 85 patients with CRC were immunostained with a monoclonal antibody against PS-PLA1. The correlation between PS-PLA1 expression and the clinicopathological variables was analyzed.

Results: Tumor depth and hematogenous metastasis independently positively correlated with PS-PLA1 expression. High PS-PLA1 expression was associated with shorter disease-free survival, although it was not an independent predictive factor.

Conclusion: PS-PLA1 expression in CRC is associated with tumor invasion and metastasis.

Keywords: Colorectal cancer; immunohistochemistry; metastasis; phosphatidylserine-specific phospholipase A1; tumor invasion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Colorectal Neoplasms / enzymology*
  • Colorectal Neoplasms / pathology
  • Disease-Free Survival
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Neoplastic Cells, Circulating
  • Phosphatidylserines / metabolism*
  • Phospholipases A1 / analysis
  • Phospholipases A1 / physiology*

Substances

  • Phosphatidylserines
  • Phospholipases A1