Background: The function of phosphatidylserine-specific phospholipase A1 (PS-PLA1), a phospholipase that acts specifically on phosphatidylserine and produces lysophosphatidylserine, a lysophospholipid mediator, has not been fully elucidated. We evaluated the role of PS-PLA1 in oncogenesis and metastasis of colorectal cancer (CRC).
Materials and methods: Specimens from 85 patients with CRC were immunostained with a monoclonal antibody against PS-PLA1. The correlation between PS-PLA1 expression and the clinicopathological variables was analyzed.
Results: Tumor depth and hematogenous metastasis independently positively correlated with PS-PLA1 expression. High PS-PLA1 expression was associated with shorter disease-free survival, although it was not an independent predictive factor.
Conclusion: PS-PLA1 expression in CRC is associated with tumor invasion and metastasis.
Keywords: Colorectal cancer; immunohistochemistry; metastasis; phosphatidylserine-specific phospholipase A1; tumor invasion.
Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.