Nasoalveolar molding in cleft care--experience in 40 patients from a single centre in Germany

PLoS One. 2015 Mar 3;10(3):e0118103. doi: 10.1371/journal.pone.0118103. eCollection 2015.

Abstract

Nasoalveolar molding (NAM) has gained wide acceptance and evidence in cleft therapy. However, standardized treatment protocols and experiences recorded from European centres are lacking. The results of 40 infants with cleft lip and palate treated with presurgical NAM according to the Grayson technique were analyzed. Standardized parameters of cleft width and nasal symmetry were measured in pre- and posttreatment plaster casts and in digitalized 3-dimensional STL models. Statistical analyses were performed by using Student's t-test in a per-protocol manner. 27 out of 40 infants completed NAM and were analyzed. In 13 patients NAM was either temporarily interrupted or terminated prematurely due to skin irritations or lack of parental support. These cases were excluded from statistical analysis, resulting in a drop-out rate of 32.5%. Intersegmental alveolar distance (ISAD), intersegmental lip distance (ISLD), nostril height (NH), nostril width (NW) and columella deviation angle (CDA) were significantly changed in unilateral cleft lip and palate (UCLP) (n = 8). In unilateral cleft lip (UCL) (n = 9), only ISLD, NH and CDA were significantly changed. ISAD of the right and left side, ISLD of the right and left side, premaxilla deviation angle, nostril height and columella length were changed significantly in bilateral cleft lip and palate (BCLP) cases (n = 10). NAM is a suitable presurgical treatment modality. A positive effect has been seen in UCLP and BCLP infants, as compared with their birth status.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthropometry
  • Cleft Lip / pathology
  • Cleft Lip / surgery*
  • Cleft Palate / pathology
  • Cleft Palate / surgery*
  • Female
  • Humans
  • Infant
  • Lip / abnormalities
  • Lip / surgery*
  • Male
  • Nose / abnormalities
  • Nose / surgery*
  • Plastic Surgery Procedures
  • Preoperative Care / methods*
  • Treatment Outcome

Grants and funding

None of the authors had any financial and personal relationships with other people or organizations that could have inappropriately influenced this work. The concept of integrating NAM into the cleft treatment protocol was financially supported by the German Research Foundation (DFG, Nasoalveolar Molding (NAM) in cleft patients) and the Bavarian Research Foundation (Bayerische Forschungsstiftung, Rehabilitation of pediatric facial deformities) through travelling sponsorships of D.J.L. Furthermore, this work was supported by the German Research Foundation (DFG) and the Technische Universität München within the funding program Open Access Publishing. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.