Redox imaging using genetically encoded redox indicators in zebrafish and mice

Biol Chem. 2015 May;396(5):511-22. doi: 10.1515/hsz-2014-0294.

Abstract

Redox signals have emerged as important regulators of cellular physiology and pathology. The advent of redox imaging in vertebrate systems now provides the opportunity to dynamically visualize redox signaling during development and disease. In this review, we summarize recent advances in the generation of genetically encoded redox indicators (GERIs), introduce new redox imaging strategies, and highlight key publications in the field of vertebrate redox imaging. We also discuss the limitations and future potential of in vivo redox imaging in zebrafish and mice.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biosensing Techniques / methods*
  • Green Fluorescent Proteins / genetics*
  • Mice
  • Oxidation-Reduction
  • Reactive Oxygen Species / metabolism*
  • Signal Transduction
  • Zebrafish

Substances

  • Reactive Oxygen Species
  • Green Fluorescent Proteins