RASSF4 promotes EV71 replication to accelerate the inhibition of the phosphorylation of AKT

Fengfeng Zhang; Yongjuan Liu; Xiong Chen; Lanlan Dong; Bingfei Zhou; Qingqing Cheng; Song Han; Zhongchun Liu; Biwen Peng; Xiaohua He; Wanhong Liu

doi:10.1016/j.bbrc.2015.02.035

RASSF4 promotes EV71 replication to accelerate the inhibition of the phosphorylation of AKT

Biochem Biophys Res Commun. 2015 Mar 20;458(4):810-5. doi: 10.1016/j.bbrc.2015.02.035. Epub 2015 Feb 19.

Authors

Fengfeng Zhang¹, Yongjuan Liu², Xiong Chen³, Lanlan Dong³, Bingfei Zhou³, Qingqing Cheng³, Song Han³, Zhongchun Liu⁴, Biwen Peng³, Xiaohua He⁵, Wanhong Liu⁶

Affiliations

¹ Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; Hubei Province Key Laboratory of Allergy and Immunology, Wuhan 430071, China.
² Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
³ Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
⁴ Institute of Neuropsychiatry, Renmin Hospital, Wuhan University, Wuhan 430060, China.
⁵ Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China. Electronic address: hexiaohua@whu.edu.cn.
⁶ Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; Hubei Province Key Laboratory of Allergy and Immunology, Wuhan 430071, China. Electronic address: liuwanhong@whu.edu.cn.

PMID: 25701784
DOI: 10.1016/j.bbrc.2015.02.035

Abstract

Enterovirus 71 (EV71) is a neurotropic virus that causes hand, foot and mouth disease (HFMD), occasionally leading to death. As a member of the RAS association domain family (RASSFs), RASSF4 plays important roles in cell death, tumor development and signal transduction. However, little is known about the relationship between RASSF4 and EV71. Our study reveals for the first time that RASSF4 promotes EV71 replication and then accelerates AKT phosphorylation inhibition in EV71-infected 293T cells, suggesting that RASSF4 may be a potential new target for designing therapeutic measures to prevent and control EV71 infection.

Keywords: AKT phosphorylation; Enterovirus 71; RASSF4; Replication.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis
Cell Line
Enterovirus A, Human / physiology*
Hand, Foot and Mouth Disease / physiopathology
Hand, Foot and Mouth Disease / virology*
Host-Pathogen Interactions*
Humans
Phosphorylation
Proto-Oncogene Proteins c-akt / metabolism*
Tumor Suppressor Proteins / metabolism*
Virus Replication*

Substances

RASSF4 protein, human
Tumor Suppressor Proteins
Proto-Oncogene Proteins c-akt