Drugs and Sleep Apneas? A review of the French Pharmacovigilance database

Therapie. 2015 Jul-Aug;70(4):347-50. doi: 10.2515/therapie/2014218. Epub 2015 Feb 16.

Abstract

The present work reviews the case reports of drug-induced sleep apnea recorded in the French pharmacovigilance database. Notifications are very rare (around 1/100 000 notifications). This paper shows that sleep apnea can be aggravated or revealed by some drugs. Main drugs involved were psychotropics (benzodiazepines, neuroleptics) and opioids.

MeSH terms

  • Adult
  • Adverse Drug Reaction Reporting Systems*
  • Aged
  • Databases, Factual
  • Drug-Related Side Effects and Adverse Reactions / epidemiology*
  • Female
  • France / epidemiology
  • Humans
  • Male
  • Middle Aged
  • Pharmacovigilance
  • Retrospective Studies
  • Sleep Apnea Syndromes / chemically induced
  • Sleep Apnea Syndromes / epidemiology*