MOST: a software environment for constraint-based metabolic modeling and strain design

Bioinformatics. 2015 Feb 15;31(4):610-1. doi: 10.1093/bioinformatics/btu685. Epub 2014 Oct 17.

Abstract

Summary: MOST (metabolic optimization and simulation tool) is a software package that implements GDBB (genetic design through branch and bound) in an intuitive user-friendly interface with excel-like editing functionality, as well as implementing FBA (flux balance analysis), and supporting systems biology markup language and comma-separated values files. GDBB is currently the fastest algorithm for finding gene knockouts predicted by FBA to increase production of desired products, but GDBB has only been available on a command line interface, which is difficult to use for those without programming knowledge, until the release of MOST.

Availability and implementation: MOST is distributed for free on the GNU General Public License. The software and full documentation are available at http://most.ccib.rutgers.edu/.

Contact: dslun@rutgers.edu.

MeSH terms

  • Algorithms*
  • Animals
  • Computational Biology / methods*
  • Gene Knockout Techniques*
  • Metabolic Flux Analysis / methods*
  • Metabolic Networks and Pathways*
  • Models, Biological*
  • Software*