MS susceptibility is not affected by single nucleotide polymorphisms in the MMP9 gene

J Neuroimmunol. 2015 Feb 15:279:46-9. doi: 10.1016/j.jneuroim.2015.01.008. Epub 2015 Jan 23.

Abstract

Matrix metalloproteinase 9 (MMP9) plays an important role in the pathogenesis of multiple sclerosis (MS). However, the impact of genetic variants affecting MMP9 on MS susceptibility is still in debate. We could not detect an association of MMP9 SNPs with MS on a genome-wide significance level by SNP genotyping, followed by imputation of SNPs within a region stretching 2Mbp up- and down-stream of MMP9. Rs6073751, located within WFDC2, was found associated with MS most strongly. Rs3918242, associated with MS according to previous reports, showed nominal significance only. Meta-analysis of our own and published data did not confirm this effect.

Keywords: GWAS; Imputation; MMP9; Multiple sclerosis; Susceptibility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study
  • Genotype
  • Germany
  • Humans
  • Male
  • Matrix Metalloproteinase 9 / genetics*
  • Meta-Analysis as Topic
  • Middle Aged
  • Multiple Sclerosis / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • Young Adult

Substances

  • Matrix Metalloproteinase 9