Expression of interleukin-9 and its upstream stimulating factors in rats with ischemic stroke

Neurol Sci. 2015 Jun;36(6):913-20. doi: 10.1007/s10072-015-2096-2. Epub 2015 Feb 5.

Abstract

To investigate the temporal expressions of IL-9 and its related cytokines after middle cerebral artery occlusion in rats. IL-9 and its related cytokines in ischemia brain and blood were tested after rats were subjected to transient focal ischemia. Comparing with sham-operated group, the levels of IL-4, TGF-β, PU.1, IRF4, OX40, NIK, RelB-p52 and IL-9 in experimental groups were significantly higher after middle cerebral artery occlusion. The results showed that expressions of IL-9 and its upstream stimulating factors increased in experimental stroke, and whether they play a role or just a secondary change is awaiting further research.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Ischemia / metabolism*
  • Cytokines / metabolism*
  • Disease Models, Animal
  • Infarction, Middle Cerebral Artery / metabolism
  • Interleukin-9 / metabolism*
  • Male
  • RNA, Messenger / biosynthesis
  • Rats, Sprague-Dawley
  • Reperfusion Injury / metabolism
  • Stroke / metabolism*

Substances

  • Cytokines
  • Interleukin-9
  • RNA, Messenger