Chromosomal mapping of the mouse IL-4 and human IL-5 genes

Genomics. 1989 Jan;4(1):47-52. doi: 10.1016/0888-7543(89)90313-3.

Abstract

We mapped the mouse interleukin (IL)-4 gene on chromosome 11 by restriction fragment length polymorphism using recombinant inbred mouse strains. The human IL-5 gene was mapped on chromosome 5q 23.3-31.1 by in situ hybridization. Because the granulocyte macrophage colony-stimulating factor (GM-CSF) and IL-3 genes were previously mapped on mouse chromosome 11 (within a 230-kb region) and human chromosome 5, the IL-4 and IL-5 genes are likely to cluster on the same chromosomes with the GM-CSF and IL-3 genes in both species.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosomes, Human, Pair 5
  • Colony-Stimulating Factors / genetics
  • Granulocyte-Macrophage Colony-Stimulating Factor
  • Growth Substances / genetics
  • Humans
  • Interleukin-3 / genetics
  • Interleukin-4
  • Interleukin-5
  • Interleukins / genetics*
  • Mice
  • Mice, Inbred Strains
  • Multigene Family
  • Nucleic Acid Hybridization
  • Polymorphism, Restriction Fragment Length
  • Recombination, Genetic
  • Restriction Mapping

Substances

  • Colony-Stimulating Factors
  • Growth Substances
  • Interleukin-3
  • Interleukin-5
  • Interleukins
  • Interleukin-4
  • Granulocyte-Macrophage Colony-Stimulating Factor