Abstract
We mapped the mouse interleukin (IL)-4 gene on chromosome 11 by restriction fragment length polymorphism using recombinant inbred mouse strains. The human IL-5 gene was mapped on chromosome 5q 23.3-31.1 by in situ hybridization. Because the granulocyte macrophage colony-stimulating factor (GM-CSF) and IL-3 genes were previously mapped on mouse chromosome 11 (within a 230-kb region) and human chromosome 5, the IL-4 and IL-5 genes are likely to cluster on the same chromosomes with the GM-CSF and IL-3 genes in both species.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chromosomes, Human, Pair 5
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Colony-Stimulating Factors / genetics
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Granulocyte-Macrophage Colony-Stimulating Factor
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Growth Substances / genetics
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Humans
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Interleukin-3 / genetics
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Interleukin-4
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Interleukin-5
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Interleukins / genetics*
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Mice
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Mice, Inbred Strains
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Multigene Family
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Nucleic Acid Hybridization
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Polymorphism, Restriction Fragment Length
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Recombination, Genetic
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Restriction Mapping
Substances
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Colony-Stimulating Factors
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Growth Substances
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Interleukin-3
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Interleukin-5
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Interleukins
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Interleukin-4
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Granulocyte-Macrophage Colony-Stimulating Factor