Notch signaling and ageing

Adv Exp Med Biol. 2015:822:25-36. doi: 10.1007/978-3-319-08927-0_6.

Abstract

Notch signaling is a master controller of the neural stem cell and neural development maintaining a significant role in the normal brain function. Notch genes are involved in embryogenesis, nervous system, and cardiovascular and endocrine function. On the other side, there are studies representing the involvement of Notch mutations in sporadic Alzheimer disease, other neurodegenerative diseases such as Down syndrome, Pick's and Prion's disease, and CADASIL. This manuscript attempts to present a holistic view of the positive or negative contribution of Notch signaling in the adult brain, and at the same time to present and promote the promising research fields of study.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / genetics
  • Aging / metabolism*
  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism
  • Animals
  • CADASIL / genetics
  • CADASIL / metabolism*
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Mutation
  • Neurodegenerative Diseases / genetics
  • Neurodegenerative Diseases / metabolism
  • Receptor, Notch3
  • Receptors, Notch / genetics
  • Receptors, Notch / metabolism*
  • Signal Transduction*

Substances

  • NOTCH3 protein, human
  • Receptor, Notch3
  • Receptors, Notch