Bone Morphogenetic Protein (BMP) signaling in development and human diseases

Richard N Wang; Jordan Green; Zhongliang Wang; Youlin Deng; Min Qiao; Michael Peabody; Qian Zhang; Jixing Ye; Zhengjian Yan; Sahitya Denduluri; Olumuyiwa Idowu; Melissa Li; Christine Shen; Alan Hu; Rex C Haydon; Richard Kang; James Mok; Michael J Lee; Hue L Luu; Lewis L Shi

doi:10.1016/j.gendis.2014.07.005

Bone Morphogenetic Protein (BMP) signaling in development and human diseases

Genes Dis. 2014 Sep;1(1):87-105. doi: 10.1016/j.gendis.2014.07.005.

Authors

Richard N Wang¹, Jordan Green¹, Zhongliang Wang², Youlin Deng², Min Qiao², Michael Peabody³, Qian Zhang², Jixing Ye⁴, Zhengjian Yan², Sahitya Denduluri¹, Olumuyiwa Idowu¹, Melissa Li³, Christine Shen³, Alan Hu³, Rex C Haydon³, Richard Kang³, James Mok³, Michael J Lee³, Hue L Luu³, Lewis L Shi³

Affiliations

¹ The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA ; Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA.
² Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA ; Departments of Orthopaedic Surgery, Medicine, and Gynecology, the Affiliated Hospitals of Chongqing Medical University, Chongqing 400016, China.
³ Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA.
⁴ Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA ; School of Bioengineering, Chongqing University, Chongqing, China.

Abstract

Bone Morphogenetic Proteins (BMPs) are a group of signaling molecules that belongs to the Transforming Growth Factor-β (TGF-β) superfamily of proteins. Initially discovered for their ability to induce bone formation, BMPs are now known to play crucial roles in all organ systems. BMPs are important in embryogenesis and development, and also in maintenance of adult tissue homeostasis. Mouse knockout models of various components of the BMP signaling pathway result in embryonic lethality or marked defects, highlighting the essential functions of BMPs. In this review, we first outline the basic aspects of BMP signaling and then focus on genetically manipulated mouse knockout models that have helped elucidate the role of BMPs in development. A significant portion of this review is devoted to the prominent human pathologies associated with dysregulated BMP signaling.

Keywords: BMP signaling; Development; Genetics; Mouse knockout; Pathogenesis; Signal transduction.

Abstract

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