Abstract
High-risk human papillomavirus (HPV) E6 proteins have a C-terminal PDZ binding motif through which they bind, and target for proteasome-mediated degradation, a number of PDZ-containing cellular targets. Recent studies have suggested that the RING-containing ubiquitin-protein ligase PDZRN3 might also be an HPV E6 target. In this analysis, we show that HPV-16 and HPV-18 E6 can target PDZRN3 in a PDZ- and proteasome-dependent manner and provide a connection between the HPV life cycle and differentiation-related STAT signaling.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carrier Proteins / metabolism*
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DNA-Binding Proteins / metabolism*
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Female
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Host-Pathogen Interactions*
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Human papillomavirus 16 / physiology*
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Human papillomavirus 18 / physiology*
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Humans
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Oncogene Proteins, Viral / metabolism*
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Proteasome Endopeptidase Complex / metabolism
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Proteolysis
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Repressor Proteins / metabolism*
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Ubiquitin-Protein Ligases
Substances
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Carrier Proteins
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DNA-Binding Proteins
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E6 protein, Human papillomavirus type 16
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E6 protein, Human papillomavirus type 18
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Oncogene Proteins, Viral
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Repressor Proteins
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PDZRN3 protein, human
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Ubiquitin-Protein Ligases
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Proteasome Endopeptidase Complex