Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

Affiliations

• ¹ 1] Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300 RC, The Netherlands [2] The Netherlands Consortium for Healthy Ageing, Leiden 2300 RC, The Netherlands.
• ² 1] Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300 RC, The Netherlands [2] Department of Cardiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
• ³ Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.
• ⁴ 1] Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M6BQ, UK [2] NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK.
• ⁵ Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
• ⁶ 1] NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK [2] Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M6BQ, UK.
• ⁷ 1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215-1204, USA [2] Harvard Medical School, Boston, Massachusetts 02215, USA.
• ⁸ Montreal Heart Institute, Universite de Montreal, Montreal H1T 1C8, Quebec, Canada.
• ⁹ Cardiovascular Health Research Unit, Department of Medicine, University of Washington, 98101 Seattle, Washington, USA.
• ¹⁰ Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
• ¹¹ Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02215, USA.
• ¹² Department of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee 37240, USA.
• ¹³ California Pacific Medical Center Research Institute, San Francisco, California 94107, USA.
• ¹⁴ 1] Icelandic Heart Association, IS-201 Kopavogur, Iceland [2] University of Iceland, IS-101 Reykjavik, Iceland.
• ¹⁵ 1] Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands [2] Health Care Inspectorate, 2595 AN The Hague, The Netherlands.
• ¹⁶ Framingham Heart Study (FHS) of the National Heart, Lung and Blood Institute, Cardiovascular Epidemiology and Human Genomics, Framingham, Massachusetts 01702, USA.
• ¹⁷ Faculty of Medicine, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G31 2ER, UK.
• ¹⁸ Department of Pharmacology and Therapeutics, University College Cork, Cork 30, Ireland.
• ¹⁹ Robertson Center for Biostatistics, University of Glasgow, Glasgow G12 8QQ, UK.
• ²⁰ 1] Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300 RC, The Netherlands [2] The Netherlands Consortium for Healthy Ageing, Leiden 2300 RC, The Netherlands [3] Leyden Academy of Vitality and Ageing, 2333 AA Leiden, The Netherlands.
• ²¹ 1] The Netherlands Consortium for Healthy Ageing, Leiden 2300 RC, The Netherlands [2] Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
• ²² Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, Glasgow G12 8QQ, UK.
• ²³ International Centre for Circulatory Health, Imperial College, London SW7 2AZ, UK.
• ²⁴ 1] Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland [2] Beaumont Hospital, Dublin 9, Ireland.
• ²⁵ 1] The Conway Institute, University College Dublin, Dublin 4, Ireland [2] School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland.
• ²⁶ The Conway Institute, University College Dublin, Dublin 4, Ireland.
• ²⁷ Department of Genome Sciences, University of Washington, Seattle, Washington 98101, USA.
• ²⁸ Department of Cardiology, Academic Medical Center, 1100 DD Amsterdam, The Netherlands.
• ²⁹ Department of Vascular Medicine, Academic Medical Center, 1100 DD Amsterdam, The Netherlands.
• ³⁰ University of Edinburgh, Edinburgh EH9 3JR, UK.
• ³¹ University of Oxford, Oxford OX1 2JD, UK.
• ³² Cardiovascular Research Group, School of Biosciences, University of Manchester, Manchester M13 9NT, UK.
• ³³ 1] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK [2] Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK [3] Oxford NIHR Biomedical Research Centre, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK.
• ³⁴ Department of Clinical Sciences/Diabetes &Endocrinology, Lund University, Malmo 205 02, Sweden.
• ³⁵ Department of Biostatistics, University of Washington, 98115 Seattle, Washington, USA.
• ³⁶ 1] Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA [2] Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101, USA [3] Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, Washington 98101, USA.
• ³⁷ 1] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, 98101 Seattle, Washington, USA [2] Department of Statistic, University of Auckland, Auckland 1142, New Zealand.
• ³⁸ 1] Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA [2] Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
• ³⁹ Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
• ⁴⁰ 1] NHLBI Framingham Heart Study, Framingham, Massachusetts 01701, USA [2] Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA [3] National Heart, Lung and Blood Institute, Bethesda, Maryland 20892, USA.
• ⁴¹ Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, and the Framingham Heart Study, Framingham, Massachusetts 01701, USA.
• ⁴² Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee 37240, USA.
• ⁴³ Department of Internal Medicine, Center for IMAGENETICS, Sanford Healthcare, Fargo, North Dakota, 58104 USA.
• ⁴⁴ 1] Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA [2] Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101, USA [3] Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA.
• ⁴⁵ Department of Cardiology, Johns Hopkins University, Baltimore, Maryland 21218, USA.
• ⁴⁶ 1] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, 98101 Seattle, Washington, USA [2] Division of Cardiology, Harborview Medical Center, University of Washington, Seattle 98101, Washington, USA.
• ⁴⁷ Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
• ⁴⁸ Division of Public Health Sciences, Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
• ⁴⁹ Department of Internal Medicine, Section on Cardiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
• ⁵⁰ Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
• ⁵¹ Icelandic Heart Association, IS-201 Kopavogur, Iceland.
• ⁵² Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Bethesda, Maryland 20892, USA.
• ⁵³ Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215-1204, USA.
• ⁵⁴ Personalised Healthcare and Biomarkers, AstraZeneca, Alderley Park SK10 4TG, UK.
• ⁵⁵ 1] AstraZeneca Research and Development, 481 83 Mölndal, Sweden [2] Unit of Occupational and Environmental Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden.
• ⁵⁶ 1] Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands [2] Health Care Inspectorate, 2595 AN The Hague, The Netherlands [3] Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
• ⁵⁷ 1] The Netherlands Consortium for Healthy Ageing, Leiden 2300 RC, The Netherlands [2] Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands [3] Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
• ⁵⁸ 1] The Netherlands Consortium for Healthy Ageing, Leiden 2300 RC, The Netherlands [2] Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
• ⁵⁹ Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
• ⁶⁰ Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
• ⁶¹ 1] Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee 37240, USA [2] Department of Medicine, Vanderbilt University, Vanderbilt, Tennessee 37240, USA.
• ⁶² Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
• ⁶³ 1] Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02215, USA [2] NHLBI Framingham Heart Study, Framingham, Massachusetts 01701, USA.
• ⁶⁴ 1] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, 98101 Seattle, Washington, USA [2] Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA [3] Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101, USA [4] Department of Health Services, University of Washington, Seattle, Washington 98101, USA.
• ⁶⁵ 1] Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK [2] Department of Public Health, University of Dundee, Dundee DD1 9SY, UK.
• ⁶⁶ Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
• ⁶⁷ Children's Hospital Oakland Research Institute, Oakland, California 94609, USA.
• ⁶⁸ 1] Department of Cardiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands [2] Durrer Center for Cardiogenetic Research, 1105 AZ Amsterdam, The Netherlands [3] Interuniversity Cardiology Institute of the Netherlands, 3511 GC Utrecht, The Netherlands.