Comorbidity of fear of progression and anxiety disorders in cancer patients

Gen Hosp Psychiatry. 2014 Nov-Dec;36(6):613-9. doi: 10.1016/j.genhosppsych.2014.08.006. Epub 2014 Aug 16.

Abstract

Objective: The relation between fear of progression (FoP) and anxiety disorders remains unclear. Therefore, we investigated the comorbidity between clinical FoP and psychiatric anxiety disorders.

Method: In this cross-sectional study, 341 cancer patients undergoing acute inpatient care participated. A structured clinical interview (Structured Clinical Interview for DSM-IV Axis I) was used to identify Diagnostic and Statistical Manual of Mental Disorders: Fourth Edition anxiety disorders and hypochondriasis. Patients completed measures of FoP (Fear of Progression Questionnaire), worries (Penn State Worry Questionnaire, Worry Domains Questionnaire), depression [Patient Health Questionnaire (PHQ): Depression], anxiety (PHQ: General Anxiety Disorder) and somatic symptoms (PHQ: Somatic Symptoms). We cross-tabulated FoP with the presence of anxiety disorders and studied associated variables.

Results: Of all patients studied, 17.6% suffered from an anxiety disorder. With regard to comorbidity, 68.3% suffered neither from clinical FoP nor from any anxiety disorder, 13.4% had not been diagnosed with an anxiety disorder but experienced clinical FoP, and 11.6% only suffered from an anxiety disorder. The remaining 6.7% suffered from FoP that was comorbid with an anxiety disorder. Patients with a pure FoP did not differ from patients with a pure anxiety disorder on nearly all symptom measures. Only a few associations between the comorbidity pattern and sociodemographic and clinical variables emerged.

Conclusion: Clinical FoP appears to be a distinct phenomenon. It does not differ from anxiety disorders in its psychological and somatic burdens.

Keywords: Anxiety disorders; Fear of progression; Fear of recurrence; Illness-related fears; Psycho-oncology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anxiety Disorders / epidemiology
  • Anxiety Disorders / psychology*
  • Comorbidity
  • Cross-Sectional Studies
  • Disease Progression*
  • Fear / psychology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasms / psychology*
  • Young Adult