Abstract
Background:
Breast cancer is the most common malignancy in women worldwide, including Thailand, and is a major cause of mortality and morbidity, despite advances in diagnosis and treatment. Novel gene expression in breast cancer is a focus in searches for prognostic biomarkers and new therapeutic targets.
Materials and methods:
The mRNA expression of novel B4GALT4, SLC35B2, and WDHD1 genes in breast cancer were examined in invasive ductal breast carcinoma (IDC) patients using quantitative real-time reverse transcription polymerase chain reaction (QRT-PCR).
Results:
Among these genes, increased expression of SLC35B2 mRNA was significantly associated with TNM stage III+IV of IDC (p<0.001). Hence, up-regulation of SLC35B2 may serve as a prognostic biomarker for poor prognosis, and is also a potential therapeutic target in breast cancer.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Aged
-
Aged, 80 and over
-
Biomarkers, Tumor / genetics*
-
Breast / metabolism
-
Breast Neoplasms / genetics*
-
Breast Neoplasms / pathology*
-
Carcinoma, Ductal, Breast / genetics
-
Carcinoma, Ductal, Breast / secondary
-
Carcinoma, Lobular / genetics
-
Carcinoma, Lobular / secondary
-
DNA-Binding Proteins / genetics*
-
Female
-
Follow-Up Studies
-
Gene Expression Regulation, Neoplastic
-
Humans
-
Lymphatic Metastasis
-
Membrane Transport Proteins / genetics*
-
Middle Aged
-
Neoplasm Invasiveness
-
Neoplasm Staging
-
Neoplasms / drug therapy*
-
Neoplasms / pathology
-
Prognosis
-
RNA, Messenger / genetics
-
Real-Time Polymerase Chain Reaction
-
Reverse Transcriptase Polymerase Chain Reaction
-
Sulfate Transporters
Substances
-
Biomarkers, Tumor
-
DNA-Binding Proteins
-
Membrane Transport Proteins
-
RNA, Messenger
-
SLC35B2 protein, human
-
Sulfate Transporters
-
WDHD1 protein, human