Introduction: The high-affinity IgE receptor (FcɛRIβ subunit int 2) gene polymorphism is a candidate gene in atopic diseases and is associated with atopy. The aim of this biochemical study was to investigate the association of its intronic mutation and allergic rhinitis in a Polish population.
Materials and methods: 100 atopic patients and 85 controls were included in the study. Polymerase chain reaction-based analysis for FcɛRIβ subunit int 2 gene polymorphism was used for genotyping and detection.
Results: There was a difference in the frequencies of genotypes of FcɛRIβ subunit int 2 in allergic rhinitis patients and controls. The FcɛRIβ subunit int 2 gene polymorphism was found to be associated with allergic rhinitis in the Polish cohort.
Conclusion: The results indicate that genetic factors may play an important role in the allergic rhinitis development in the investigated group.
Keywords: Allergic rhinitis; Atopy; FcɛRIβ subunit int 2; Gene polymorphism.
Copyright © 2014 Polish Otorhinolaryngology - Head and Neck Surgery Society. Published by Elsevier Urban & Partner Sp. z.o.o. All rights reserved.