[Prostate and bladder cancer: detection of disseminated tumor cells in bone marrow]

R Nawroth; D Weckermann; M Retz

doi:10.1007/s00120-014-3445-0

[Prostate and bladder cancer: detection of disseminated tumor cells in bone marrow]

Urologe A. 2014 Apr;53(4):514-8. doi: 10.1007/s00120-014-3445-0.

[Article in German]

Authors

R Nawroth¹, D Weckermann, M Retz

Affiliation

¹ Klinik und Poliklinik für Urologie, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Straße 22, 81675, München, Deutschland, roman.nawroth@lrz.tum.de.

PMID: 24671250
DOI: 10.1007/s00120-014-3445-0

Abstract

The prognosis of prostate and bladder cancer patients is predominantly determined by the detection of distant sites of metastasis. In clinical routine, virtually only lymph node staging is of relevance to determine metastasis. Detection and characterization of disseminated tumor cells in peripheral blood or bone marrow is an additional parameter of prognostic significance. In this article, we will summarize recent progress on the prognostic value of disseminated tumor cells in bone marrow and its translation into routine clinical analysis.

Publication types

English Abstract
Review

MeSH terms

Biomarkers, Tumor / analysis
Biomarkers, Tumor / genetics
Bone Marrow / pathology
Bone Marrow Neoplasms / genetics
Bone Marrow Neoplasms / mortality
Bone Marrow Neoplasms / pathology*
Bone Marrow Neoplasms / secondary*
Disease Progression
Humans
Keratin-18 / genetics
Keratin-20 / genetics
Lymph Nodes / pathology
Lymphatic Metastasis / pathology
Male
Molecular Diagnostic Techniques*
Neoplasm Recurrence, Local / genetics
Neoplasm Recurrence, Local / mortality
Neoplasm Recurrence, Local / pathology
Neoplasm Staging / methods
Prognosis
Prostate / pathology
Urinary Bladder Neoplasms / genetics*
Urinary Bladder Neoplasms / mortality
Urinary Bladder Neoplasms / pathology*

Substances

Biomarkers, Tumor
Keratin-18
Keratin-20