Calcium-signal facilitates herpes simplex virus type 1 nuclear transport through slingshot 1 and calpain-1 activation

Virus Res. 2014 Aug 8:188:32-7. doi: 10.1016/j.virusres.2014.03.016. Epub 2014 Mar 23.

Abstract

Herpes simplex virus type 1 (HSV-1) can establish its latency in neurons and is associated with virus-induced pathological neurodegeneration in the nervous system. Here we show that viral penetration-induced calcium release facilitated HSV-1 intracellular trafficking through activating slingshot 1 (SSH), a phosphatase regulating actin filament dynamics. More detailed studies revealed that phospholipase C gamma 1, and the inositol 1,4,5-trisphosphate receptor isoform 1 were required for SSH activation. Besides, calpain-1, a calcium-dependent cysteine protease, was involved in viral intracellular migration. These results may lead to new targets for antiviral therapy.

Keywords: Calcium signal; Calpain-1; Herpes simplex virus type 1 (HSV-1); Nuclear transport; Slingshot 1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Active Transport, Cell Nucleus*
  • Calcium / metabolism*
  • Calpain / metabolism*
  • Herpesvirus 1, Human / physiology*
  • Humans
  • Phosphoprotein Phosphatases / metabolism*
  • Virus Latency*

Substances

  • Phosphoprotein Phosphatases
  • SSH1 protein, human
  • Calpain
  • Calcium