Sequence and expression of human GABAA receptor alpha 1 and beta 1 subunits

P R Schofield; D B Pritchett; H Sontheimer; H Kettenmann; P H Seeburg

doi:10.1016/0014-5793(89)80563-0

Sequence and expression of human GABAA receptor alpha 1 and beta 1 subunits

FEBS Lett. 1989 Feb 27;244(2):361-4. doi: 10.1016/0014-5793(89)80563-0.

Authors

P R Schofield¹, D B Pritchett, H Sontheimer, H Kettenmann, P H Seeburg

Affiliation

¹ Zentrum für Molekulare Biologie, University of Heidelberg, FRG.

PMID: 2465923
DOI: 10.1016/0014-5793(89)80563-0

Abstract

The deduced amino acid sequences of cDNA clones encoding human GABAA receptor alpha 1 and beta 1 subunits are presented. The human subunits display very high levels of sequence identity with the corresponding bovine receptor subunits. The cloned human GABAA receptor subunits induce the formation of GABA-gated chloride channels when expressed in mammalian cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Base Sequence
Brain / metabolism*
Chloride Channels
Chlorides / physiology
Cloning, Molecular
DNA / genetics
DNA / isolation & purification
Fetus
Humans
Ion Channels / drug effects
Ion Channels / physiology
Macromolecular Substances
Membrane Potentials / drug effects
Membrane Proteins / physiology
Molecular Sequence Data
Receptors, GABA-A / genetics*
Transfection
gamma-Aminobutyric Acid / pharmacology

Substances

Chloride Channels
Chlorides
Ion Channels
Macromolecular Substances
Membrane Proteins
Receptors, GABA-A
gamma-Aminobutyric Acid
DNA