Supratentorial ependymomas of childhood carry C11orf95-RELA fusions leading to pathological activation of the NF-κB signaling pathway

Acta Neuropathol. 2014 Apr;127(4):609-11. doi: 10.1007/s00401-014-1264-4. Epub 2014 Feb 22.
No abstract available

Publication types

  • Letter

MeSH terms

  • Child
  • Child, Preschool
  • DNA Mutational Analysis
  • Ependymoma / genetics*
  • Ependymoma / pathology
  • Female
  • Humans
  • Infant
  • Male
  • NF-kappa B / metabolism*
  • Proteins / genetics*
  • Proteins / metabolism
  • RNA, Messenger / metabolism
  • Signal Transduction / genetics
  • Signal Transduction / physiology*
  • Supratentorial Neoplasms / genetics*
  • Supratentorial Neoplasms / pathology
  • Transcription Factor RelA / genetics*
  • Transcription Factor RelA / metabolism

Substances

  • C11orf95 protein, human
  • NF-kappa B
  • Proteins
  • RELA protein, human
  • RNA, Messenger
  • Transcription Factor RelA