Association of adiponectin gene -11377C>G polymorphism with adiponectin levels and the metabolic syndrome in Thais

Asia Pac J Clin Nutr. 2014;23(1):167-73. doi: 10.6133/apjcn.2014.23.1.01.

Abstract

The metabolic syndrome is related to increased risk of developing cardiovascular disease and type 2 diabetes. Adiponectin is an adipocyte-secreted protein with insulin-sensitizing and anti-atherogenic properties. The aims of this study were to evaluate adiponectin levels and biochemical parameters in metabolic-syndrome subjects and healthy controls. The study also sought to identify links between two polymorphisms, -11377C>G (rs266729) and +45T>G (rs2241766) of the adiponectin gene, in relation to adiponectin levels and the metabolic syndrome. Three hundres and thirty-two Thai volunteers: 164 metabolic-syndrome subjects and 168 healthy control subjects were investigated. The adiponectin and HDL-C levels of the metabolic-syndrome group were significantly lower than the control group (p<0.001). Decreased concentration of adiponectin was associated with -11377C>G polymorphism (p<0.001); this polymorphism was significantly more frequent in the metabolic syndrome group than in the control group (p<0.001). However, +45T>G polymorphism of the adiponectin gene was found not to be related to adiponectin level or metabolic syndrome. Therefore, -11377C>G polymorphism was related to the metabolic syndrome susceptibility, and this polymorphism impacted on circulating adiponectin concentrations among Thais.

代謝症候群與增加心血管疾病及第二型糖尿病罹患風險具有相關性。脂聯素 是一種由脂肪細胞分泌的蛋白質,具有促進胰島素敏感性及抗動脈粥狀硬化 的特性。本篇研究目的為評估代謝症候群患者與健康對照者的脂聯素濃度及 生化參數。另外也探討兩個脂聯素基因-11377C>G(rs266729) 與 +45T>C(rs2241766)的多型性與脂聯素濃度和代謝症候群間的關聯性。332 名 泰國志願者:164 名代謝症候群患者與168 名健康對照者為研究對象。代謝症 候群組的脂聯素與HDL-C 濃度顯著低於對照組(p<0.001)。較低的脂聯素濃度 與-11377C>G 基因多型性有關(p<0.001);此多型性在代謝症候群組比例顯著多 於對照組(p<0.001)。然而,脂聯素基因+45T>C 的多型性與脂聯素濃度或是代 謝症候群沒有相關性。因此,-11377C>G 多型性與代謝症候群的易感受性有 關,而這個多型性影響泰國人血液循環中的脂聯素濃度。

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / blood*
  • Adiponectin / genetics*
  • Adult
  • Blood Glucose / analysis
  • Blood Pressure
  • Body Mass Index
  • Cholesterol, HDL / blood
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Insulin / blood
  • Metabolic Syndrome / blood*
  • Metabolic Syndrome / genetics*
  • Middle Aged
  • Polymorphism, Genetic / genetics*
  • Polymorphism, Single Nucleotide
  • Thailand
  • Triglycerides / blood
  • Waist Circumference
  • Waist-Hip Ratio

Substances

  • Adiponectin
  • Blood Glucose
  • Cholesterol, HDL
  • Insulin
  • Triglycerides