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MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity.
Mol Cell. 2014 Mar 6;53(5):726-37. doi: 10.1016/j.molcel.2014.01.013. Epub 2014 Feb 20.
Mol Cell. 2014.
PMID: 24560927
Free PMC article.
The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) Uptake.
Petrungaro C, Zimmermann KM, Küttner V, Fischer M, Dengjel J, Bogeski I, Riemer J.
Petrungaro C, et al.
Cell Metab. 2015 Oct 6;22(4):721-33. doi: 10.1016/j.cmet.2015.08.019. Epub 2015 Sep 17.
Cell Metab. 2015.
PMID: 26387864
Free article.
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High-affinity cooperative Ca2+ binding by MICU1-MICU2 serves as an on-off switch for the uniporter.
Kamer KJ, Grabarek Z, Mootha VK.
Kamer KJ, et al.
EMBO Rep. 2017 Aug;18(8):1397-1411. doi: 10.15252/embr.201643748. Epub 2017 Jun 14.
EMBO Rep. 2017.
PMID: 28615291
Free PMC article.
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Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex.
Fan M, Zhang J, Tsai CW, Orlando BJ, Rodriguez M, Xu Y, Liao M, Tsai MF, Feng L.
Fan M, et al.
Nature. 2020 Jun;582(7810):129-133. doi: 10.1038/s41586-020-2309-6. Epub 2020 May 20.
Nature. 2020.
PMID: 32494073
Free PMC article.
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