PTPLAD2 is a tumor suppressor in esophageal squamous cell carcinogenesis

Shaojun Zhu; Zhipeng Wang; Zhipei Zhang; Jian Wang; Yanhong Li; Li Yao; Qibing Mei; Wei Zhang

doi:10.1016/j.febslet.2014.01.058

PTPLAD2 is a tumor suppressor in esophageal squamous cell carcinogenesis

FEBS Lett. 2014 Mar 18;588(6):981-9. doi: 10.1016/j.febslet.2014.01.058. Epub 2014 Feb 14.

Authors

Shaojun Zhu¹, Zhipeng Wang², Zhipei Zhang³, Jian Wang⁴, Yanhong Li⁵, Li Yao⁶, Qibing Mei⁷, Wei Zhang⁸

Affiliations

¹ The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China. Electronic address: zhusjly@fmmu.edu.cn.
² Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China. Electronic address: zhipengw@fmmu.edu.cn.
³ Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China. Electronic address: zhangzhipei2013@hotmail.com.
⁴ Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China. Electronic address: wjtm1976@163.com.
⁵ The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China; Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China. Electronic address: lyhzhw@fmmu.edu.cn.
⁶ The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China. Electronic address: yaoli@fmmu.edu.cn.
⁷ Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China. Electronic address: qbmei@fmmu.edu.cn.
⁸ The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China. Electronic address: zhwlyh@fmmu.edu.cn.

PMID: 24530685
DOI: 10.1016/j.febslet.2014.01.058

Abstract

Esophageal squamous cell carcinomas (ESCCs) are highly invasive and have poor prognoses. We investigated the role of PTPLAD2, a protein tyrosine phosphatase-like A domain (PTPLAD) family member, in ESCC carcinogenesis. Survival analysis was performed using patient data. ESCC tissue samples lost PTPLAD2 heterozygosity and had decreased PTPLAD2 expression. Low PTPLAD2 expression and high p-STAT3 correlated with poor prognosis. Overexpression of PTPLAD2 in ESCC cells reduced STAT3 phosphorylation, decreased FoxM1, inhibited proliferation and decreased in mouse xenograft tumor formation. Therefore, PTPLAD2 is a potential tumor suppressor and prognostic indicator that reduces STAT3 phosphorylation. PTPLAD2 is a possible clinical target for ESCC treatment.

Keywords: Esophageal cancer; PTPLAD2; Prognosis; Proliferation; Signal transducer and activator of transcription 3.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Carcinogenesis / metabolism*
Carcinogenesis / pathology
Carcinoma, Squamous Cell / metabolism*
Carcinoma, Squamous Cell / mortality
Carcinoma, Squamous Cell / pathology
Cell Line, Tumor
Cell Proliferation
Esophageal Neoplasms / metabolism*
Esophageal Neoplasms / mortality
Esophageal Neoplasms / pathology
Esophageal Squamous Cell Carcinoma
Female
Forkhead Box Protein M1
Forkhead Transcription Factors / genetics
Forkhead Transcription Factors / metabolism
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Humans
Hydro-Lyases
Kaplan-Meier Estimate
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Middle Aged
NIH 3T3 Cells
Neoplasm Transplantation
Phosphorylation
Protein Processing, Post-Translational
STAT3 Transcription Factor / metabolism
Tumor Burden
Tumor Suppressor Proteins / physiology*

Substances

FOXM1 protein, human
Forkhead Box Protein M1
Forkhead Transcription Factors
STAT3 Transcription Factor
STAT3 protein, human
Tumor Suppressor Proteins
Hydro-Lyases
HACD4 protein, human