TDP-43 in ALS: stay on target…almost there

Neuron. 2014 Feb 5;81(3):463-5. doi: 10.1016/j.neuron.2014.01.034.

Abstract

ALS is associated with RNA processing impairments involving the RNA-binding protein TDP-43. Pioneering a novel RNA beacon to illuminate RNA trafficking in neurons, Alami et al. (2014) discover a cytoplasmic function for TDP-43, suggesting a new disease mechanism.

MeSH terms

  • Amyotrophic Lateral Sclerosis / genetics*
  • Amyotrophic Lateral Sclerosis / pathology
  • Animals
  • DNA-Binding Proteins / genetics*
  • Humans
  • Mutation / genetics*
  • Neurons / metabolism
  • Neurons / pathology
  • RNA / metabolism

Substances

  • DNA-Binding Proteins
  • RNA