Comparative genomic analysis of eutherian ribonuclease A genes

Mol Genet Genomics. 2014 Apr;289(2):161-7. doi: 10.1007/s00438-013-0801-5. Epub 2013 Dec 15.

Abstract

The present study attempted to update comprehensive eutherian ribonuclease A gene data sets, using public eutherian genomic sequence data sets and new genomics and molecular evolution tests. Among 448 ribonuclease A potential coding sequences, the present analysis annotated 255 complete coding sequences. The most comprehensive data set of eutherian ribonuclease A genes first characterized 13 major gene clusters, 9 of which showed evidence of differential gene expansions. In addition, the present analysis described common predicted promoter regions of eutherian ribonuclease A genes. The present study also attempted to resolve discrepancies in descriptions of eutherian ribonuclease A genes. Thus, the integrated gene annotations, phylogenetic analysis and protein molecular evolution analysis proposed new classification and nomenclature of eutherian ribonuclease A genes, as new framework of future experiments.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Evolution, Molecular*
  • Genome
  • Genomics*
  • Mammals / genetics*
  • Molecular Sequence Annotation*
  • Phylogeny
  • Ribonuclease, Pancreatic / classification
  • Ribonuclease, Pancreatic / genetics*

Substances

  • Ribonuclease, Pancreatic