[Intraductal papillary neoplasms of the bile duct (IPNB). Diagnostic criteria, carcinogenesis and differential diagnostics]

Pathologe. 2013 Nov:34 Suppl 2:235-40. doi: 10.1007/s00292-013-1861-3.
[Article in German]

Abstract

Intraductal papillary neoplasms of the bile duct (IPNB) are rare precursor lesions of intrahepatic and extrahepatic cholangiocarcinoma that follow an adenoma-carcinoma sequence. According to the histomorphology and the distinct immunohistochemical mucin pattern, four different subtypes are recognized: pancreatobiliary, intestinal, gastric and oncocytic. Differential diagnoses include micropapillary lesions (biliary intraepithelial neoplasms), papillary cystic lesions (intraductal tubulopapillary neoplasms) and cystic lesions (mucinous cystic neoplasms).

Publication types

  • English Abstract
  • Review

MeSH terms

  • Bile Duct Neoplasms / classification
  • Bile Duct Neoplasms / diagnosis
  • Bile Duct Neoplasms / pathology*
  • Bile Ducts, Extrahepatic / pathology*
  • Bile Ducts, Intrahepatic / pathology*
  • Biomarkers, Tumor / analysis
  • Carcinoma, Pancreatic Ductal / classification
  • Carcinoma, Pancreatic Ductal / diagnosis
  • Carcinoma, Pancreatic Ductal / pathology
  • Carcinoma, Papillary / classification
  • Carcinoma, Papillary / diagnosis
  • Carcinoma, Papillary / pathology*
  • Cell Transformation, Neoplastic / pathology
  • Cholangiocarcinoma / diagnosis
  • Cholangiocarcinoma / pathology*
  • Diagnosis, Differential
  • Female
  • Humans
  • Liver / pathology
  • Male
  • Middle Aged
  • Mucins / analysis
  • Neoplasm Invasiveness
  • Neoplasm Staging
  • Pancreas / pathology
  • Precancerous Conditions / classification
  • Precancerous Conditions / diagnosis
  • Precancerous Conditions / pathology*
  • Prognosis
  • Terminology as Topic
  • World Health Organization

Substances

  • Biomarkers, Tumor
  • Mucins