Primary structure of the alpha-subunit of bovine adenylate cyclase-inhibiting G-protein deduced from the cDNA sequence

T Nukada; T Tanabe; H Takahashi; M Noda; K Haga; T Haga; A Ichiyama; K Kanagawa; M Hiranaga; Matsuo

doi:10.1016/0014-5793(86)80347-7

Primary structure of the alpha-subunit of bovine adenylate cyclase-inhibiting G-protein deduced from the cDNA sequence

FEBS Lett. 1986 Mar 3;197(1-2):305-10. doi: 10.1016/0014-5793(86)80347-7.

Authors

T Nukada, T Tanabe, H Takahashi, M Noda, K Haga, T Haga, A Ichiyama, K Kanagawa, M Hiranaga, Matsuo, et al.

PMID: 2419165
DOI: 10.1016/0014-5793(86)80347-7

Abstract

The primary structure of the alpha-subunit of the adenylate cyclase-inhibiting G-protein (Gi) has been deduced from the nucleotide sequence of cloned DNA complementary to the bovine cerebral mRNA encoding the polypeptide. A much higher degree of amino acid sequence homology is observed between the alpha-subunits of Gi and transducin (68%) than between those of Gi and the adenylate cyclase-stimulating G-protein (Gs) (43%) or between those of transducin and Gs (42%).

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adenylyl Cyclase Inhibitors*
Amino Acid Sequence
Animals
Base Sequence
Brain Chemistry
Cattle
DNA*
DNA, Recombinant
GTP-Binding Proteins / genetics*
Membrane Proteins / genetics
Nucleic Acid Hybridization
Peptide Fragments
Poly A / genetics
RNA / genetics
RNA, Messenger
Transducin

Substances

Adenylyl Cyclase Inhibitors
DNA, Recombinant
Membrane Proteins
Peptide Fragments
RNA, Messenger
Poly A
RNA
DNA
GTP-Binding Proteins
Transducin

Associated data

GENBANK/X03642