Convenient synthesis of (68)Ga-labeled gadolinium(III) complexes: towards bimodal responsive probes for functional imaging with PET/MRI

Chemistry. 2013 Sep 16;19(38):12602-6. doi: 10.1002/chem.201302751.

Abstract

A killer application? Recently, fully integrated full-body positron-emission tomography (PET) and magnetic-resonance imaging (MRI) scanners were brought to market, allowing simultaneous recording of complementary 3D data sets. By using bimodal PET/MRI probes (see figure), in vivo 3D mapping of various parameters with medical relevance could become feasible.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Contrast Media / chemical synthesis
  • Contrast Media / chemistry
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / chemistry*
  • Gadolinium / chemistry*
  • Heterocyclic Compounds, 1-Ring / chemistry
  • Kidney / diagnostic imaging
  • Magnetic Resonance Imaging
  • Positron-Emission Tomography
  • Radiography
  • Radiopharmaceuticals / chemical synthesis
  • Radiopharmaceuticals / chemistry
  • Rats
  • Rats, Wistar

Substances

  • Contrast Media
  • Coordination Complexes
  • Heterocyclic Compounds, 1-Ring
  • Radiopharmaceuticals
  • 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
  • Gadolinium