Helicobacter pylori antibody responses and evolution of precancerous gastric lesions in a Chinese population

Int J Cancer. 2014 May 1;134(9):2118-25. doi: 10.1002/ijc.28560. Epub 2013 Nov 7.

Abstract

Helicobacter pylori-specific proteins are involved in gastric carcinogenesis. To investigate the seroprevalence of six H. pylori-specific antibodies in patients with different gastric histology, and the impact of seropositivities on the evolution of precancerous gastric lesions, a follow-up study was conducted in Linqu County, China. The seropositivities for CagA, VacA, GroEL, UreA, HcpC and gGT were assessed by recomLine analysis in 573 H. pylori-positive subjects and correlated with evolution of precancerous gastric lesions. We found that the score of H. pylori recomLine test was significantly increased in subjects with chronic atrophic gastritis (CAG, p < 0.0001) or intestinal metaplasia (IM, p = 0.0125), and CagA was an independent predictor of advanced gastric lesions, adjusted odds ratios (ORs) were 2.54 (95% CI = 1.42-4.55) for IM and 2.38 (95% CI = 1.05-5.37) for dysplasia (DYS). Moreover, seropositivities for CagA and GroEL were identified as independent predictors for progression of gastric lesions in a longitudinal study, and ORs were 2.89 (95% CI = 1.27-6.59) and 2.20 (95% CI = 1.33-3.64), respectively. Furthermore, the risk of progression was more pronounced in subjects with more than three positive antigens (p(for) trend = 0.0003). This population-based study revealed that seropositivities for CagA and GroEL might be potential markers to identify patients infected with high-risk H. pylori strains, which are related to the development of GC in a Chinese high-risk population, and recomLine test might serve as a tool for risk stratification.

Keywords: Helicobacter pylori; gastric cancer; precancerous gastric lesions; protein; serology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Bacterial / blood*
  • Antigens, Bacterial / immunology
  • Asian People
  • Bacterial Proteins / immunology
  • Chaperonin 60 / immunology
  • Helicobacter Infections / complications
  • Helicobacter Infections / immunology*
  • Helicobacter pylori / immunology
  • Humans
  • Precancerous Conditions / immunology*
  • Precancerous Conditions / microbiology
  • Precancerous Conditions / pathology
  • Randomized Controlled Trials as Topic
  • Seroepidemiologic Studies
  • Stomach Neoplasms / immunology*
  • Stomach Neoplasms / microbiology
  • Stomach Neoplasms / pathology

Substances

  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Bacterial Proteins
  • Chaperonin 60
  • cagA protein, Helicobacter pylori