Abstract
Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system that leads to demyelination and neurodegeneration. VIP and PACAP are structurally related neuropeptides with neuroprotective and anti-inflammatory activities. To evaluate VIP and PACAP-38 in plasma and CSF in humans in correlation with IL-6, IL-10 and TNFα, we compared 20 MS individuals with 27 healthy controls. In MS, a decrease in PACAP-38 in CSF and a decrease in plasma IL-6 concentration were seen. A positive correlation between plasma VIP and plasma IL-6 was identified. We conclude that VIP and PACAP may influence the course of MS.
Keywords:
IL-10; IL-6; Multiple sclerosis; PACAP; TNFα; VIP.
© 2013.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Biomarkers / blood
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Biomarkers / cerebrospinal fluid
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Female
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Humans
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Male
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Multiple Sclerosis / blood*
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Multiple Sclerosis / cerebrospinal fluid*
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Multiple Sclerosis / diagnosis
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Pituitary Adenylate Cyclase-Activating Polypeptide / blood
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Pituitary Adenylate Cyclase-Activating Polypeptide / cerebrospinal fluid
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Pituitary Adenylate Cyclase-Activating Polypeptide / physiology*
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Vasoactive Intestinal Peptide / blood
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Vasoactive Intestinal Peptide / cerebrospinal fluid
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Vasoactive Intestinal Peptide / physiology*
Substances
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ADCYAP1 protein, human
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Biomarkers
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Pituitary Adenylate Cyclase-Activating Polypeptide
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Vasoactive Intestinal Peptide