Atom hopping: A chlorophosphite-mediated Beckmann ligation of oximes and p-toluenesulfonyl azide gives access to N-sulfonyl phosphoramidines in good to excellent yields. The reaction proceeds under exceptionally mild conditions and constitutes a bioorthogonal approach toward amidines by avoiding the use of amines and transition-metal catalysts. dmp-ol=3,3-dimethylpropanediol.
Keywords: Beckmann rearrangement; amidines; azides; oximes; rearrangement.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.