Mitochondrial carrier homolog 1 (Mtch1) antibodies in neuro-Behçet's disease

J Neuroimmunol. 2013 Oct 15;263(1-2):139-44. doi: 10.1016/j.jneuroim.2013.08.007. Epub 2013 Aug 24.

Abstract

Efforts for the identification of diagnostic autoantibodies for neuro-Behcet's disease (NBD) have failed. Screening of NBD patients' sera with protein macroarray identified mitochondrial carrier homolog 1 (Mtch1), an apoptosis-related protein, as a potential autoantigen. ELISA studies showed serum Mtch1 antibodies in 68 of 144 BD patients with or without neurological involvement and in 4 of 168 controls corresponding to a sensitivity of 47.2% and specificity of 97.6%. Mtch1 antibody positive NBD patients had more attacks, increased disability and lower serum nucleosome levels. Mtch1 antibody might be involved in pathogenic mechanisms of NBD rather than being a coincidental byproduct of autoinflammation.

Keywords: Anti-neuronal antibody; Antibody; Autoimmunity; Behçet's disease; Mitochondrial carrier homolog 1; Neuro-Behçet's disease.

MeSH terms

  • Adult
  • Animals
  • Autoantibodies / biosynthesis*
  • Autoantibodies / blood
  • Behcet Syndrome / diagnosis*
  • Behcet Syndrome / etiology
  • Behcet Syndrome / immunology*
  • Biomarkers / blood
  • Female
  • Humans
  • Male
  • Membrane Proteins / blood
  • Membrane Proteins / immunology*
  • Mitochondrial Proteins / blood
  • Mitochondrial Proteins / immunology*
  • Nucleosomes / immunology
  • Nucleosomes / metabolism
  • Rats

Substances

  • Autoantibodies
  • Biomarkers
  • MTCH1 protein, human
  • Membrane Proteins
  • Mitochondrial Proteins
  • Nucleosomes