Stress-induced cellular transcription factors expressed in trigeminal ganglionic neurons stimulate the herpes simplex virus 1 ICP0 promoter

J Virol. 2013 Dec;87(23):13042-7. doi: 10.1128/JVI.02476-13. Epub 2013 Sep 11.

Abstract

Alphaherpesvirinae family members can reactivate from latency following stress. The synthetic corticosteroid dexamethasone induces certain cellular transcription factors in murine and bovine trigeminal ganglionic neurons. Three dexamethasone-induced transcription factors, Krüppel-like factor 15, Slug, and SPDEF, stimulated the herpes simplex virus type 1-infected cell protein 0 (ICP0) promoter more than 150-fold. Conversely, other viral promoters (VP16 and ICP4) were not strongly stimulated, suggesting that the ICP0 promoter is preferentially activated by dexamethasone-simulated stress.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dexamethasone / pharmacology
  • Female
  • Gene Expression Regulation, Viral
  • Herpes Simplex / genetics
  • Herpes Simplex / metabolism*
  • Herpes Simplex / physiopathology
  • Herpes Simplex / virology
  • Herpesvirus 1, Human / genetics*
  • Herpesvirus 1, Human / metabolism
  • Humans
  • Immediate-Early Proteins / genetics*
  • Immediate-Early Proteins / metabolism
  • Kruppel-Like Transcription Factors / genetics
  • Kruppel-Like Transcription Factors / metabolism*
  • Mice
  • Neurons / drug effects
  • Neurons / metabolism
  • Neurons / virology
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • Promoter Regions, Genetic*
  • Proto-Oncogene Proteins c-ets / genetics
  • Proto-Oncogene Proteins c-ets / metabolism*
  • Snail Family Transcription Factors
  • Stress, Physiological
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*
  • Trigeminal Ganglion / drug effects
  • Trigeminal Ganglion / metabolism*
  • Trigeminal Ganglion / virology
  • Ubiquitin-Protein Ligases / genetics*
  • Ubiquitin-Protein Ligases / metabolism
  • Up-Regulation

Substances

  • Immediate-Early Proteins
  • KLF15 protein, human
  • Kruppel-Like Transcription Factors
  • Nuclear Proteins
  • Proto-Oncogene Proteins c-ets
  • SNAI1 protein, human
  • SPDEF protein, human
  • Snai2 protein, mouse
  • Snail Family Transcription Factors
  • Transcription Factors
  • Dexamethasone
  • Ubiquitin-Protein Ligases
  • Vmw110 protein, Human herpesvirus 1