Abstract
Alphaherpesvirinae family members can reactivate from latency following stress. The synthetic corticosteroid dexamethasone induces certain cellular transcription factors in murine and bovine trigeminal ganglionic neurons. Three dexamethasone-induced transcription factors, Krüppel-like factor 15, Slug, and SPDEF, stimulated the herpes simplex virus type 1-infected cell protein 0 (ICP0) promoter more than 150-fold. Conversely, other viral promoters (VP16 and ICP4) were not strongly stimulated, suggesting that the ICP0 promoter is preferentially activated by dexamethasone-simulated stress.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Dexamethasone / pharmacology
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Female
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Gene Expression Regulation, Viral
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Herpes Simplex / genetics
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Herpes Simplex / metabolism*
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Herpes Simplex / physiopathology
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Herpes Simplex / virology
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Herpesvirus 1, Human / genetics*
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Herpesvirus 1, Human / metabolism
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Humans
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Immediate-Early Proteins / genetics*
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Immediate-Early Proteins / metabolism
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Kruppel-Like Transcription Factors / genetics
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Kruppel-Like Transcription Factors / metabolism*
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Mice
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Neurons / drug effects
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Neurons / metabolism
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Neurons / virology
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism*
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Promoter Regions, Genetic*
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Proto-Oncogene Proteins c-ets / genetics
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Proto-Oncogene Proteins c-ets / metabolism*
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Snail Family Transcription Factors
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Stress, Physiological
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Transcription Factors / genetics
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Transcription Factors / metabolism*
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Trigeminal Ganglion / drug effects
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Trigeminal Ganglion / metabolism*
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Trigeminal Ganglion / virology
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Ubiquitin-Protein Ligases / genetics*
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Ubiquitin-Protein Ligases / metabolism
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Up-Regulation
Substances
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Immediate-Early Proteins
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KLF15 protein, human
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Kruppel-Like Transcription Factors
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Nuclear Proteins
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Proto-Oncogene Proteins c-ets
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SNAI1 protein, human
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SPDEF protein, human
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Snai2 protein, mouse
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Snail Family Transcription Factors
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Transcription Factors
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Dexamethasone
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Ubiquitin-Protein Ligases
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Vmw110 protein, Human herpesvirus 1