Abstract
The authors examined the association between the MspI C/G and DraI C/T genotypes of the α2A-adrenergic receptor gene and white-matter connectivity and attentional performance before and after medication in 53 children with attention-deficit hyperactivity disorder. Subjects who carried the T allele at the DraI polymorphism showed fewer changes in the mean commission error scores after 8 weeks of medication and decreased fractional anisotropy (FA) values in the right middle frontal cortex than subjects without the T allele. Subjects with the C allele at the MspI polymorphism showed decreased FA values in the right postcentral gyrus than subjects without.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Anisotropy
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Attention Deficit Disorder with Hyperactivity* / drug therapy
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Attention Deficit Disorder with Hyperactivity* / genetics
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Attention Deficit Disorder with Hyperactivity* / pathology
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Central Nervous System Stimulants / therapeutic use*
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Child
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Diffusion Magnetic Resonance Imaging
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Female
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Gene Frequency
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Genotype
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Humans
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Male
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Methylphenidate / therapeutic use*
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Nerve Fibers, Myelinated / pathology*
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Polymorphism, Single Nucleotide / genetics*
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Receptors, Adrenergic, alpha-2 / genetics*
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Republic of Korea
Substances
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Central Nervous System Stimulants
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Receptors, Adrenergic, alpha-2
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Methylphenidate