Meta-analysis of the correlation between PTPN22 gene polymorphisms and susceptibility to systemic lupus erythematosus

Asia Pac J Public Health. 2013 Jul;25(4 Suppl):22S-9S. doi: 10.1177/1010539513496268.

Abstract

In this meta-analysis of the association between PTPN22 gene polymorphisms and susceptibility to systemic lupus erythematosus, 4 case-control studies, including one from China, were included. The studies included 1864 participants: 772 cases and 1092 controls. The meta-analysis showed that the 1858C/T polymorphism of the PTPN22 gene is correlated with systemic lupus erythematosus susceptibility, when assessed by distribution characteristics such as nationality, race, and region. A large sample size from the Chinese population is required for a further prospective study before causality can be established.

Keywords: 1858C/T polymorphism; PTPN22 gene; meta-analysis; systemic lupus erythematosus (SLE).

Publication types

  • Meta-Analysis

MeSH terms

  • Case-Control Studies
  • China
  • Genetic Predisposition to Disease*
  • Humans
  • Lupus Erythematosus, Systemic / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • Protein Tyrosine Phosphatase, Non-Receptor Type 22 / genetics*

Substances

  • PTPN22 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 22