Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase

Angew Chem Int Ed Engl. 2013 Sep 23;52(39):10384-7. doi: 10.1002/anie.201304290. Epub 2013 Aug 14.

Authors

Florian Schlauderer¹, Katja Lammens, Daniel Nagel, Michelle Vincendeau, Andrea C Eitelhuber, Steven H L Verhelst, Dale Kling, Al Chrusciel, Jürgen Ruland, Daniel Krappmann, Karl-Peter Hopfner

Affiliation

¹ Gene Center, Department of Biochemistry, Ludwig-Maximilians University Munich, Feodor-Lynen-Strasse 25, 80377 Munich (Germany).

PMID: 23946259
DOI: 10.1002/anie.201304290

No abstract available

Keywords: cancer; inhibitors; medicinal chemistry; multiple sclerosis; thioridazine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Allosteric Regulation / drug effects
Caspases / chemistry
Caspases / metabolism
Cell Line
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / pharmacology*
Humans
Models, Molecular
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
Neoplasm Proteins / antagonists & inhibitors*
Neoplasm Proteins / chemistry
Neoplasm Proteins / metabolism
Phenothiazines / chemistry*
Phenothiazines / pharmacology*

Substances

Enzyme Inhibitors
Neoplasm Proteins
Phenothiazines
Caspases
MALT1 protein, human
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein