Runx2 induces bone osteolysis by transcriptional suppression of TSSC1

Da-Chuan Wang; Hai-Feng Wang; Ze-Nong Yuan

doi:10.1016/j.bbrc.2013.07.131

Runx2 induces bone osteolysis by transcriptional suppression of TSSC1

Biochem Biophys Res Commun. 2013 Sep 6;438(4):635-9. doi: 10.1016/j.bbrc.2013.07.131. Epub 2013 Aug 8.

Authors

Da-Chuan Wang¹, Hai-Feng Wang, Ze-Nong Yuan

Affiliation

¹ Department of Orthopedics Surgery, The Provincial Hospital Affiliated to Shandong University, Shandong, China.

PMID: 23933319
DOI: 10.1016/j.bbrc.2013.07.131

Abstract

Advanced breast cancers frequently metastasize to bone, resulting in osteolytic lesions, however, the underlying mechanisms are poorly understood. Runx2, a bone-specific transcriptional factor, is abnormally expressed in highly metastatic breast cancer cells. Here, we found that TSSC1 inhibits breast cancer cell invasion. Subsequently, TSSC1 is confirmed as a target of Runx2 and is negatively regulated by Runx2. Furthermore, overexpression of Runx2 induces bone osteolysis in a TSSC1-dependent manner. Our results may provide a strategy for the treatment of breast cancer and the prevention of skeletal metastasis.

Keywords: Breast cancer; Osteolytic lesions; Runx2; TSSC1.

MeSH terms

Animals
Bone Neoplasms / genetics
Bone Neoplasms / metabolism
Bone Neoplasms / pathology
Bone Neoplasms / secondary*
Bone and Bones / metabolism
Bone and Bones / pathology*
Breast / metabolism
Breast / pathology
Breast Neoplasms / genetics
Breast Neoplasms / metabolism
Breast Neoplasms / pathology*
Cell Line, Tumor
Core Binding Factor Alpha 1 Subunit / genetics
Core Binding Factor Alpha 1 Subunit / metabolism*
Female
Gene Expression Regulation, Neoplastic
Humans
Mice
Mice, SCID
Neoplasm Invasiveness / genetics
Neoplasm Invasiveness / pathology
Nuclear Proteins / genetics*
Nuclear Proteins / metabolism
Osteolysis*
Up-Regulation

Substances

Core Binding Factor Alpha 1 Subunit
EIPR1 protein, human
Nuclear Proteins
TSSC1 protein, mouse