Cloning and sequencing of a cDNA encoding human mi...[FEBS Lett. 1990]

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1: FEBS Lett. 1990 Aug 20;269(1):153-6.Links

Cloning and sequencing of a cDNA encoding human milk beta-casein.

Lönnerdal B, Bergström S, Andersson Y, Hjalmarsson K, Sundqvist AK, Hernell O.

Department of Nutrition, University of California, Davis 95616.

A cDNA of 1065 bp encoding the human milk beta-casein was cloned and sequenced using a synthetic oligodeoxyribonucleotide probe and a human mammary gland library. The nucleotide (nt) sequence contained an open reading frame sufficient to encode the entire amino-acid (aa) sequence of a beta-casein precursor protein consisting of 210 aa and a signal peptide of 15 aa. The nt sequence shows 45-62% homology to those of bovine, ovine, rat, and mouse beta-caseins. The highly phosphorylated site, which is responsible for the calcium-binding capacity of beta-casein, the signal peptide, and a sequence encoding for an inhibitor to the angiotensin-converting enzyme seem highly conserved among the beta-caseins with known sequences.

PMID: 2387396 [PubMed - indexed for MEDLINE]

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Construction and identification of recombinant plasmids carrying cDNAs coding for ovine alpha S1-, alpha S2-, beta-, kappa-casein and beta-lactoglobulin. Nucleotide sequence of alpha S1-casein cDNA. [Biochimie. 1985]
Complete nucleotide sequence of ovine beta-casein cDNA: inter-species comparison. [Biochimie. 1989]
Cloning and sequence analysis of bovine beta-casein cDNA. [Biochem Biophys Res Commun. 1987]
Human phosvitin/casein kinase type II. Molecular cloning and sequencing of full-length cDNA encoding subunit beta. [Eur J Biochem. 1989]

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Cloning and sequencing of a cDNA encoding human milk beta-casein.

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