Pitpnm1 is expressed in hair cells during development but is not required for hearing

Neuroscience. 2013 Sep 17:248:620-5. doi: 10.1016/j.neuroscience.2013.06.045. Epub 2013 Jun 29.

Abstract

Deafness is a genetically complex disorder with many contributing genes still unknown. Here we describe the expression of Pitpnm1 in the inner ear. It is expressed in the inner hair cells of the organ of Corti from late embryonic stages until adulthood, and transiently in the outer hair cells during early postnatal stages. Despite this specific expression, Pitpnm1 null mice showed no hearing defects, possibly due to redundancy with the paralogous genes Pitpnm2 and Pitpnm3.

Keywords: Mir96; Pitpnm1; deafness; hair cell; inner ear; mouse mutant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / physiology*
  • Animals
  • Ear, Inner / cytology*
  • Eye Proteins / genetics
  • Eye Proteins / metabolism*
  • Gene Expression Regulation, Developmental
  • Hair Cells, Auditory, Inner / metabolism*
  • Hearing / genetics
  • Hearing / physiology*
  • Hearing Tests
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Phospholipid Transfer Proteins / deficiency
  • Phospholipid Transfer Proteins / genetics
  • Phospholipid Transfer Proteins / metabolism*

Substances

  • Eye Proteins
  • Phospholipid Transfer Proteins
  • Pitpnm1 protein, mouse