Clonal mast cell activation syndrome with anaphylaxis to sulfites

Int Arch Allergy Immunol. 2013;162(1):94-6. doi: 10.1159/000348379. Epub 2013 Jun 27.

Abstract

Sulfites are rarely suspected as causative agents of immediate-type hypersensitivity. We report on a 49-year-old male patient who developed recurrent severe hypotension after food ingestion. A diagnosis of monoclonal mast cell activation syndrome was established. In the double-blind, placebo-controlled food challenge, the patient reacted to potassium metabisulfite with anaphylaxis.

Publication types

  • Case Reports

MeSH terms

  • Anaphylaxis / chemically induced*
  • Anaphylaxis / complications*
  • Cell Proliferation
  • Clone Cells
  • Food Hypersensitivity / diagnosis
  • Humans
  • Male
  • Mast Cells / cytology
  • Mast Cells / pathology*
  • Mastocytosis / complications
  • Mastocytosis / etiology*
  • Mastocytosis / immunology
  • Middle Aged
  • Placebos
  • Sulfites / immunology*
  • Syndrome

Substances

  • Placebos
  • Sulfites
  • potassium metabisulfite