In vitro selective inhibitory effect of 8-hydroxyquinoline against bifidobacteria and clostridia

Jitka Novakova; Eva Vlkova; Bela Bonusova; Vojtech Rada; Ladislav Kokoska

doi:10.1016/j.anaerobe.2013.05.008

In vitro selective inhibitory effect of 8-hydroxyquinoline against bifidobacteria and clostridia

Anaerobe. 2013 Aug:22:134-6. doi: 10.1016/j.anaerobe.2013.05.008. Epub 2013 Jun 14.

Authors

Jitka Novakova¹, Eva Vlkova, Bela Bonusova, Vojtech Rada, Ladislav Kokoska

Affiliation

¹ Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague, Kamycka 129, 165 21 Prague 6-Suchdol, Czech Republic. novakovajitka@its.czu.cz

PMID: 23770542
DOI: 10.1016/j.anaerobe.2013.05.008

Abstract

8-Hydroxyquinoline (8HQ) inhibited Clostridium tertium, Clostridium clostridioforme, Clostridium difficile and Clostridium perfringens in vitro with MICs of 8, 16, 32 and 32 μg/mL, respectively. In contrast, MICs of most bifidobacteria (84%) were 512 μg/mL or higher. Thus, 8HQ could be used as anti-clostridial agent or in selective media for bifidobacteria isolation.

Keywords: 8-Quinolinol; Antimicrobial activity; Bifidobacterium; Clostridium; Selectivity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Bifidobacterium / drug effects*
Bifidobacterium / isolation & purification
Clostridium / drug effects*
Clostridium / isolation & purification
Feces / microbiology*
Humans
Infant
Microbial Sensitivity Tests
Oxyquinoline / pharmacology*

Substances

Anti-Bacterial Agents
Oxyquinoline