TRIM39R, but not TRIM39B, regulates type I interferon response

Biochem Biophys Res Commun. 2013 Jun 21;436(1):90-5. doi: 10.1016/j.bbrc.2013.05.064. Epub 2013 May 23.

Abstract

Behcet's disease (BD) is a chronic relapsing inflammatory autoimmune disease characterized by recurrent oral and genital ulcers, skin legions and uveitis and its pathogenesis is not fully elucidated. Previously we identified that two novel susceptible SNPs are associated with BD. One is located in putative RNF39 promoter region, another is located on TRIM39 coding exon. In this study, in order to identify the molecular function of TRIM39, we established gain-of-function of TRIM39 related genes and thus, performed microarray analysis. Our results indicate that TRIM39R, but not TRIM39B, regulates type I interferon response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Behcet Syndrome / genetics
  • Behcet Syndrome / metabolism*
  • Bone Marrow / metabolism
  • Carrier Proteins / genetics
  • Carrier Proteins / physiology*
  • Gene Expression Regulation*
  • Genetic Predisposition to Disease
  • HEK293 Cells
  • Humans
  • Inflammation
  • Interferon Type I / metabolism*
  • Models, Genetic
  • Oligonucleotide Array Sequence Analysis
  • Polymorphism, Single Nucleotide
  • Ubiquitin-Protein Ligases
  • Virus Diseases / metabolism

Substances

  • Carrier Proteins
  • Interferon Type I
  • TRIM39 protein, human
  • Ubiquitin-Protein Ligases