The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147) - a potential novel target in atherothrombosis prevention?

Nader Joghetaei; Andreas Stein; Robert A Byrne; Christian Schulz; Lamin King; Andreas E May; Roland Schmidt

doi:10.1016/j.thromres.2013.04.017

The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147) - a potential novel target in atherothrombosis prevention?

Thromb Res. 2013 Jun;131(6):474-80. doi: 10.1016/j.thromres.2013.04.017. Epub 2013 May 10.

Authors

Nader Joghetaei¹, Andreas Stein, Robert A Byrne, Christian Schulz, Lamin King, Andreas E May, Roland Schmidt

Affiliation

¹ Deutsches Herzzentrum und I. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

PMID: 23669100
DOI: 10.1016/j.thromres.2013.04.017

Abstract

The immunoglobulin superfamily member EMMPRIN (CD147) plays an important role in a number of organ systems, including the cardiovascular system. Here we review the contemporary understanding of EMMPRIN and EMMPRIN-associated sequelae in the course of atherosclerosis. A significant body of data documents the pivotal role of EMMPRIN in the complex processes of atherogenesis, atheroprogression, and acute atherosclerothrombosis, a role that goes beyond that of a mere marker of inflammation.

Publication types

Review

MeSH terms

Animals
Arteries / immunology
Arteries / pathology*
Atherosclerosis / immunology*
Atherosclerosis / pathology*
Basigin / immunology*
Collagenases / immunology*
Humans
Inflammation / immunology
Inflammation / pathology

Substances

Basigin
Collagenases